Overview

  • Product name
    (S)-Ketoprofen, COX1/2 inhibitor
  • Description
    Highly potent COX1/2 inhibitor. Non-steroidal anti-inflammatory drug (NSAID).
  • Biological description
    Highly potent COX1/2 inhibitor (IC50 values are 19 and 54 nM for COX1 and 2 respectively). Non-steroidal anti-inflammatory drug (NSAID). Blood-brain barrier permeable.
  • Purity
    > 98%
  • CAS Number
    22161-81-5
  • Chemical structure
    Chemical Structure

Properties

Applications

Our Abpromise guarantee covers the use of ab141035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • DU145 cells were incubated at 37°C for 40h with vehicle control (0 µM) and different concentrations of (S)-Ketoprofen (ab141035) in DMSO. Decreased expression of pro-caspase 8 (ab49853) correlates with an increase in (S)-Ketoprofen concentration, as described in literature.

    Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab49853 at 1 μg/ml and ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.

References

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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