Product nameS-Me-DM1, microtubule-targeting maytansinoid
- Maytansinoid DM 1
- S-methyl DM1
Active metabolite of Maytansine (ab146096) that inhibits in vitro polymerization of tubulin. Accumulates in cells and induces mitotic arrest.
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Solubilizes at ~3mg/mL in DMSO, ~3mg/mL in Chloroform, and ~3mg/mL in MeOH
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Goldmacher VS et al. High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction. PLoS One 10:e0117523 (2015). Read more (PubMed: 25671541) »
- Prota AE et al. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc Natl Acad Sci U S A 111:13817-21 (2014). Read more (PubMed: 25114240) »
- Lopus M et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther 9:2689-99 (2010). Read more (PubMed: 20937594) »
- Oroudjev E et al. Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. Mol Cancer Ther 9:2700-13 (2010). Read more (PubMed: 20937595) »