S-Me-DM1, microtubule-targeting maytansinoid (ab216942)

Overview

  • Product name

    S-Me-DM1, microtubule-targeting maytansinoid
  • Description

    Microtubule-targeting maytansinoid
  • Alternative names

    • Maytansinoid DM 1
    • S-methyl DM1
  • Biological description

    Active metabolite of Maytansine (ab146096) that inhibits in vitro polymerization of tubulin. Accumulates in cells and induces mitotic arrest.

  • CAS Number

    912569-84-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

  • Molecular weight

    752.31
  • Molecular formula

    C36H50ClN3O10S
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Solubilizes at ~3mg/mL in DMSO, ~3mg/mL in Chloroform, and ~3mg/mL in MeOH

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Goldmacher VS  et al. High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction. PLoS One 10:e0117523 (2015). Read more (PubMed: 25671541) »
  • Prota AE  et al. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc Natl Acad Sci U S A 111:13817-21 (2014). Read more (PubMed: 25114240) »
  • Lopus M  et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther 9:2689-99 (2010). Read more (PubMed: 20937594) »
  • Oroudjev E  et al. Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. Mol Cancer Ther 9:2700-13 (2010). Read more (PubMed: 20937595) »

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