S-Methyl-N,N-diethylthiocarbamate Sulfone (MeDTC), aldehyde dehydrogenase inhibitor (ab144779)

Overview

  • Product name

    S-Methyl-N,N-diethylthiocarbamate Sulfone (MeDTC), aldehyde dehydrogenase inhibitor
  • Description

    Potent irreversible inhibitor of low Km mitochondrial aldehyde dehydrogenase (ALDH)
  • Alternative names

    • MeDTC
  • Biological description

    Potent irreversible inhibitor of low Km mitochondrial aldehyde dehydrogenase (ALDH) (IC50 = 420 nM). Dioxygenated metabolite of disulfiram. Potential use in embryogenic studies and retinoic acid signaling. Active in vitro and in vivo.
  • CAS Number

    155514-79-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Koppaka V  et al. Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacol Rev 64:520-39 (2012). Read more (PubMed: 22544865) »
  • Mays DC  et al. S-methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase. Biochem Pharmacol 49:693-700 (1995). Read more (PubMed: 7887984) »
  • Lauriault VV & O'Brien PJ Disulfiram may mediate erythrocyte hemolysis induced by diethyldithiocarbamate and 1,4-naphthoquinone-2-sulfonate. Arch Biochem Biophys 284:207-14 (1991). Read more (PubMed: 1846514) »

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