(S)-WAY 100135, 5-HT1A receptor antagonist (ab146821)

Overview

  • Product name

    (S)-WAY 100135, 5-HT1A receptor antagonist
  • Description

    Potent, selective 5-HT1A receptor antagonist
  • Biological description

    Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Active in vivo.

  • Purity

    > 99%
  • CAS Number

    149007-54-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-(-)-N-tert-Butyl-3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenylpropanamide dihydrochloride
  • Molecular weight

    468.47
  • Molecular formula

    C24H33N3O2.2HCl
  • PubChem identifier

    14801907
  • Storage instructions

    Store at room temperature.
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)NC(=O)[C@H](CN1CCN(CC1)C2=CC=CC=C2OC)C3=CC=CC=C3.Cl.Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Wedzony K  et al. WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801. Neuropsychopharmacology 23:547-59 (2000). Read more (PubMed: 11027920) »
  • Rodgers RJ & Cole JC Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. Eur J Pharmacol 261:321-5 (1994). Read more (PubMed: 7813555) »
  • Fletcher A  et al. WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur J Pharmacol 237:283-91 (1993). Read more (PubMed: 8365456) »

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