S100 beta peptide (ab30380)

Our Abpromise guarantee covers the use of ab30380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- NEF
- Protein S100 B
- Protein S100-B
- S 100 calcium binding protein beta chain
- S 100 protein beta chain
- S-100 protein beta chain
- S-100 protein subunit beta
- S100
- S100 calcium binding protein beta (neural)
- S100 calcium-binding protein B
- S100 protein beta chain
- S100B
- S100B_HUMAN
- S100beta
see all
Function

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Tissue specificity

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
Sequence similarities

Belongs to the S-101 family.
Contains 2 EF-hand domains.
Cellular localization

Cytoplasm. Nucleus.
Target information above from: UniProt accession P04271 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

ab30380 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"