S14-95, JAK/STAT pathway inhibitor (ab144515)

Overview

  • Product name

    S14-95, JAK/STAT pathway inhibitor
  • Description

    JAK/STAT pathway inhibitor
  • Purity

    > 95%
  • CAS Number

    419532-92-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,4aR,6aR,12aR,12bS)-3-(Acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-4,4,6a,12b-tetramethyl-9-phenyl-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one

  • Molecular weight

    450.57
  • Molecular formula

    C28H34O5
  • PubChem identifier

    10983241
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in Methanol.

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]3([C@@H]2CC4=C(O3)C=C(OC4=O)C5=CC=CC=C5)C)C
  • Source

    Isolated from Penicillium sp.

References

This product has been referenced in:

  • Prompanya C  et al. New Isocoumarin Derivatives and Meroterpenoids from the Marine Sponge-Associated Fungus Aspergillus similanensis sp. nov. KUFA 0013. Mar Drugs 12:5160-73 (2014). Read more (PubMed: 25317534) »
  • Yao Y  et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol 63:383-91 (2003). Read more (PubMed: 12527810) »
  • Erkel G  et al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo) 56:337-43 (2003). Read more (PubMed: 12817806) »

Customer reviews and Q&As

Abreviews
Mouse hepatocytes were pre-treated with S14-95 for 1 h, and then stimulated with 100 ng/ml LPS and 10 ng/ml INF-g for 8 h. The cells were collected for immunoblotting of COX-2.

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Verified customer

Submitted Nov 02 2018

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