Overview

  • Product name
    S14161, Apoptotic agent
  • Description
    Cyclin D1-D3 inhibitor. Phosphoinositide 3-kinase inhibitor. Apoptotic agent.
  • Biological description
    Cyclin D1-D3 inhibitor. Phosphoinositide 3-kinase inhibitor. Apoptotic agent. Induces cell cycle arrest at G0/G1 phase (IC50 < 10 μM). Shows antitumor effects in vivo. Orally active.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Han K  et al. Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization. J Hematol Oncol 7:9 (2014). Read more (PubMed: 24428908) »
  • Liu F  et al. PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma. Cancer Cell Int 13:108 (2013). Read more (PubMed: 24176221) »
  • Mao X  et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood 117:1986-97 (2011). Read more (PubMed: 21135258) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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