Overview

  • Product name

    S3I-201 (DMSO solution), STAT3 inhibitor
  • Description

    Selective STAT3 inhibitor
  • Biological description

    Selective STAT3 inhibitor (IC50 values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.

    Also available as a solid (ab141434).
  • Purity

    > 97%
  • CAS Number

    501919-59-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
  • Molecular weight

    365.36
  • Molecular formula

    C16H15NO7S
  • PubChem identifier

    252682
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Supplied in DMSO (10 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhang L  et al. Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling. Drug Des Devel Ther 9:2139-48 (2015). Read more (PubMed: 25931810) »
  • Wang ZF  et al. Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats. Neuroscience 273:65-78 (2014). Read more (PubMed: 24836854) »
  • Pang M  et al. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int 78:257-68 (2010). Read more (PubMed: 20520592) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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