Key features and details
- Selective STAT3 inhibitor
- CAS Number: 501919-59-1
- Purity: > 97%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Product nameS3I-201 (DMSO solution), STAT3 inhibitor
DescriptionSelective STAT3 inhibitor
Biological descriptionSelective STAT3 inhibitor (IC50 values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.
Also available as a solid (ab141434).
Chemical name2-Hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
Storage instructionsStore at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewSupplied in DMSO (10 mM)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146606 has been referenced in 1 publication.
- Wang Y et al. The positive feedback between lncRNA TNK2-AS1 and STAT3 enhances angiogenesis in non-small cell lung cancer. Biochem Biophys Res Commun 507:185-192 (2018). PubMed: 30454892