Recombinant Anti-SA2 antibody [EPR10993] - N-terminal (ab171970)


  • Product name

    Anti-SA2 antibody [EPR10993] - N-terminal
    See all SA2 primary antibodies
  • Description

    Rabbit monoclonal [EPR10993] to SA2 - N-terminal
  • Host species

  • Tested applications

    Suitable for: Flow Cyt, ICC/IF, WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human SA2 aa 1-100 (N terminal) (Cysteine residue). The exact sequence is proprietary.
    Database link: Q8N3U4

  • Positive control

    • MCF7 and Jurkat cells. Jurkat, K-562, MCF7 and HeLa cell lysates.
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab171970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.


ICC/IF 1/100 - 1/250.
WB 1/1000 - 1/5000. Predicted molecular weight: 141 kDa.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function

      Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
    • Sequence similarities

      Belongs to the SCC3 family.
      Contains 1 SCD (stromalin conservative) domain.
    • Post-translational

      Phosphorylated by PLK. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation.
    • Cellular localization

      Nucleus. Chromosome. Chromosome > centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
    • Information by UniProt
    • Database links

    • Alternative names

      • bA517O1.1 antibody
      • Cohesin Subunit SA 2 antibody
      • Cohesin subunit SA-2 antibody
      • DKFZp686P168 antibody
      • DKFZp781H1753 antibody
      • FLJ25871 antibody
      • SA 2 antibody
      • SA-2 antibody
      • SA2 antibody
      • SCC3 homolog 2 antibody
      • SCC3B antibody
      • STAG 2 antibody
      • stag2 antibody
      • STAG2_HUMAN antibody
      • Stromal antigen 2 antibody
      see all


    • All lanes : Anti-SA2 antibody [EPR10993] - N-terminal (ab171970) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : K-562 cell lysate
      Lane 3 : MCF7 cell lysate
      Lane 4 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : Standard HRP labeled goat anti-rabbit at 1/2000 dilution

      Developed using the ECL technique.

      Predicted band size: 141 kDa

    • Immunofluorescence analysis of MCF7 cells, labeling SA2 using ab171970 at a 1/100 dilution.

    • Flow cytometric analysis of permeabilized Jurkat cells, labeling SA2 using ab171970 at a 1/10 dilution (red) or a rabbit IgG as negative control (green).


    ab171970 has not yet been referenced specifically in any publications.

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