Key features and details
- GABAB antagonist
- CAS Number: 125464-42-8
- Purity: > 98%
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameSaclofen, GABAB antagonist
Also available in simple stock solutions (ab146704) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120327 has been referenced in 4 publications.
- Kosillo P et al. Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cereb Cortex N/A:N/A (2016). PubMed: 27566978
- Platt NJ et al. Striatal dopamine transmission is subtly modified in human A53Ta-synuclein overexpressing mice. PLoS One 7:e36397 (2012). PubMed: 22570709
- Threlfell S et al. Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons. Neuron 75:58-64 (2012). PubMed: 22794260
- Hartung H et al. Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens. Neuropsychopharmacology 36:1811-22 (2011). PubMed: 21508928