Overview

  • Product name

    Anti-Sacsin antibody [EPR11864]
    See all Sacsin primary antibodies
  • Description

    Rabbit monoclonal [EPR11864] to Sacsin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human Sacsin aa 4100-4200. The exact sequence is proprietary.
    Database link: Q9NZJ4

  • Positive control

    • Human fetal brain lysate. Human glioma lysate.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab181190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Predicted molecular weight: 521 kDa.

Target

  • Function

    Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.
  • Tissue specificity

    Highly expressed in the central nervous system. Also found in skeletal muscle and at low levels in pancreas.
  • Involvement in disease

    Spastic ataxia Charlevoix-Saguenay type
  • Sequence similarities

    Contains 1 HEPN domain.
    Contains 1 J domain.
    Contains 1 ubiquitin-like domain.
  • Domain

    The ubiquitin-like domain mediates interaction with the proteasome.
    The J domain is functional and is shown to stimulate E.coli dnaK ATPase activity.
  • Cellular localization

    Cytoplasm. Predominantly cytoplasmic, a small portion is present in the nucleus and also shows a partial mitochondrial overlap with the mitochondrial marker Hsp60.
  • Information by UniProt
  • Database links

  • Alternative names

    • DnaJ homolog subfamily C member 29 antibody
    • DNAJC29 antibody
    • SACS antibody
    • SACS_HUMAN antibody
    • Sacsin antibody
    • Spastic ataxia of Charlevoix-Saguenay antibody
    see all

Images

  • Anti-Sacsin antibody [EPR11864] (ab181190) at 1/5000 dilution + Human glioma at 20 µg

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 521 kDa
    Additional bands at: 437 kDa (possible isoform)

  • Anti-Sacsin antibody [EPR11864] (ab181190) at 1/2000 dilution + Human fetal brain at 20 µg

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 521 kDa
    Additional bands at: 437 kDa (possible isoform)

References

This product has been referenced in:

See 1 Publication for this product

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