Anti-SAF-B2 antibody [6F7] (ab67344)
Key features and details
- Mouse monoclonal [6F7] to SAF-B2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-SAF-B2 antibody [6F7]
See all SAF-B2 primary antibodies -
Description
Mouse monoclonal [6F7] to SAF-B2 -
Host species
Mouse -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human SAF-B2 aa 345-357.
Sequence:PEARDSKEDGRKF
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Positive control
- Human brain cortex tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
6F7 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab67344 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Notes |
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IHC-P: Use at a concentration of 5 µg/ml.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 108 kDa.
N.B. on SDS PAGE gels, Scaffold attachment factor B2 runs as an approximately 130 kDa protein. This aberrant migration is due to a large number of charged amino acid residues.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. -
Tissue specificity
Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines. -
Sequence similarities
Contains 1 RRM (RNA recognition motif) domain.
Contains 1 SAP domain. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Cytoplasm. Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 9667 Human
- Omim: 608066 Human
- SwissProt: Q14151 Human
- Unigene: 655392 Human
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Alternative names
- DKFZP779C1727 antibody
- HAP antibody
- HET antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab67344 has not yet been referenced specifically in any publications.