Overview

  • Product name

    SAHA (Vorinostat), HDAC inhibitor
  • Description

    Potent non-selective HDAC inhibitor
  • Alternative names

    • Vorinostat
  • Biological description

    Potent non-selective HDAC inhibitor (IC50 values are 10 and 20 nM for HDAC1 and HDAC3, respectively). Induces apoptosis and shows antiproliferative effects against cancer cell lines (IC50 = 3 - 8 μM). Antitumor effects in vivo. No effect on class III HDACs. Orally active.
  • Purity

    > 98%
  • CAS Number

    149647-78-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Thaler F & Mercurio C Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next. ChemMedChem 9:523-6 (2014). Read more (PubMed: 24730063) »
  • Rafehi H  et al. Vascular histone deacetylation by pharmacological HDAC inhibition. Genome Res : (2014). Read more (PubMed: 24732587) »

Customer reviews and Q&As

Answer

Ab144480 can either be dissolved in ethanol with warming at a concentration of 50 mM or in DMSO at a concentration of 100 mM. We recommend warming the product at 40oC in a sonicating batch (or alternatively in a 40oC bath, swirling it from times to times) for a couple of minutes. We do not record the duration necessary for the product to dissolve. So, you may have to monitor the time for completely dissolving this product.

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