Overview

  • Product name

  • Description

    Rabbit polyclonal to SAHH
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Recombinant fragment
    Predicted to work with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human SAHH (N terminal).

  • General notes

     This product was previously labelled as S adenosylhomocysteine hydrolase

     

Properties

Applications

Our Abpromise guarantee covers the use of ab56146 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

Target

  • Function

    Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
  • Pathway

    Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
  • Involvement in disease

    Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) [MIM:613752]. A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy.
  • Sequence similarities

    Belongs to the adenosylhomocysteinase family.
  • Cellular localization

    Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links

  • Alternative names

    • Adenosylhomocysteinase antibody
    • AdoHcyase antibody
    • ahcY antibody
    • S adenosyl L homocysteine hydrolase antibody
    • S adenosylhomocysteine hydrolase antibody
    • S-adenosyl-L-homocysteine hydrolase antibody
    • SAHH antibody
    • SAHH_HUMAN antibody
    see all

Images

  • All lanes : Anti-SAHH antibody (ab56146) at 1 µg/ml

    Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Predicted band size: 48 kDa
    Observed band size: 48 kDa

References

This product has been referenced in:

See 1 Publication for this product

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