Overview

  • Product name

    Saikosaponin D, glucocorticoid receptor agonist
  • Description

    Glucocorticoid receptor agonist. COX-2 and iNOS inhibitor.
  • Biological description

    Glucocorticoid receptor agonist. COX-2 and iNOS inhibitor. Saikosaponin A (ab143543) epimer. Inhibits NF-κB, TNF-α, IL-1β and IL-6. Inhibits apoptosis. Shows anti-inflammatory and antiallergic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    20874-52-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Li ZY  et al. Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway. Prog Neuropsychopharmacol Biol Psychiatry 53C:80-89 (2014). Read more (PubMed: 24636912) »
  • Chen X  et al. Effect of saikosaponins and extracts of vinegar-baked Bupleuri Radix on the activity of ß-glucuronidase. Xenobiotica : (2014). Read more (PubMed: 24641105) »
  • Lu CN  et al. Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-?B signaling pathway. Int Immunopharmacol 14:121-6 (2012). Read more (PubMed: 22728095) »

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