Product nameSaikosaponin D, glucocorticoid receptor agonist
DescriptionGlucocorticoid receptor agonist. COX-2 and iNOS inhibitor.
Biological descriptionGlucocorticoid receptor agonist. COX-2 and iNOS inhibitor. Saikosaponin A (ab143543) epimer. Inhibits NF-κB, TNF-α, IL-1β and IL-6. Inhibits apoptosis. Shows anti-inflammatory and antiallergic effects in vivo. Orally active.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Nitric oxide & oxidative stress
This product has been referenced in:
- Li ZY et al. Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway. Prog Neuropsychopharmacol Biol Psychiatry 53C:80-89 (2014). Read more (PubMed: 24636912) »
- Chen X et al. Effect of saikosaponins and extracts of vinegar-baked Bupleuri Radix on the activity of ß-glucuronidase. Xenobiotica : (2014). Read more (PubMed: 24641105) »
- Lu CN et al. Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-?B signaling pathway. Int Immunopharmacol 14:121-6 (2012). Read more (PubMed: 22728095) »