Salinomycin sodium salt, cation ionophore (ab146178)

Overview

  • Product name

    Salinomycin sodium salt, cation ionophore
  • Description

    Cation ionophore. Antibiotic agent.
  • Biological description

    Cation ionophore. Antibiotic agent. Salinomycin (ab141186) salt. Shows cancer stems cell selective antiproliferative effects (IC50 values are 24 and 90 μM for cancer stem cell subpopulation and HMLER breast cancer cells respectively). Shows antitumor effects in vivo.

  • CAS Number

    55721-31-8
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    772.98
  • Molecular formula

    C42H69NaO11
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O[Na])[C@H](CC)[C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]5O[C@]4(C=C[C@@H](O)C2(CC[C@](C)(O2)[C@H]3CC[C@](O)(CC)[C@H](C)O3)O4)[C@H](C)C[C@@H]5C
  • Source

    Streptomyces albus

References

This product has been referenced in:

  • Zhou S  et al. Salinomycin: a novel anti-cancer agent with known anti-coccidial activities. Curr Med Chem 20:4095-101 (2013). Read more (PubMed: 23931281) »
  • Matsumori N  et al. Conformation and location of membrane-bound salinomycin-sodium complex deduced from NMR in isotropic bicelles. J Am Chem Soc 129:14989-95 (2007). Read more (PubMed: 17994744) »
  • Schäfer H  et al. Cationophore properties of the new polyether antibiotic Salinomycin investigated in distal rabbit colon in vivo and in vitro. Comp Biochem Physiol A Comp Physiol 79:387-92 (1984). Read more (PubMed: 6149842) »

Customer reviews and Q&As

Question
Answer

Thank you for getting in touch.


I can confirm that the purity of ab146178 Salinomycin sodium salt is 97% by TLC (thin layer chromatography).


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