Key features and details
- Competitve PPMTase inhibitor. Ras inhibitor.
- CAS Number: 162520-00-5
- Form / State: Solid
- Source: Synthetic
Product nameSalirasib (Farnesylthiosalicylic acid), PPMTase inhibitor. Ras inhibitor
DescriptionCompetitve PPMTase inhibitor. Ras inhibitor.
Biological descriptionCompetitive PPMTase inhibitor (Ki = 2.6 μM). Ras inhibitor. Facilitates ras degradation, displacement from the plasma membrane and downstream signaling. Shows antiproliferative effects (IC50 = 7.5 µM, Rat1 fibroblasts). Induces autophagy in cancer cell lines. Shows antinecrotic, anti-inflammatory and antitumor effects in vivo. Orally active.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146188 has not yet been referenced specifically in any publications.