Overview

  • Product name

    Salsalate, AMPK activator NSAID
  • Description

    NSAID. AMPK activator.
  • Alternative names

    • Disalcid
    • Disalicylic acid
    • salicylsalicylic acid
    • Sasapirin
    • sasapyrine
    see all
  • Biological description

    NSAID. Prodrug dimer of salicylic acid (ab120746). Suppresses NF-κB activation and inhibits prostanoid production. AMPK activator. Affects blood glucose, free fatty acid and C-reactive protein concentrations. Shows analgesic and anti-inflammatory effects in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    552-94-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Hardie DG AMPK: a target for drugs and natural products with effects on both diabetes and cancer. Diabetes 62:2164-72 (2013). Read more (PubMed: 23801715) »
  • Cao Y  et al. Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats. Biopharm Drug Dispos 33:285-91 (2012). Read more (PubMed: 22782506) »
  • Desouza CV An overview of salsalate as a potential antidiabetic therapy. Drugs Today (Barc) 46:847-53 (2010). Read more (PubMed: 21225023) »
  • McCarty MF & Block KI Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy. Integr Cancer Ther 5:252-68 (2006). Read more (PubMed: 16880431) »

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