Salvinorin B, kappa-opioid DREADD (KORD) agonist (ab235503)

Overview

  • Product name

    Salvinorin B, kappa-opioid DREADD (KORD) agonist
  • Description

    A potent and selective κ-opioid DREADD (KORD) agonist
  • Alternative names

    • (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo 2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
    • Divinorin B
  • Biological description

    A potent and selective κ-opioid DREADD (KORD) agonist. DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity and behavior. Displays no analgesic or ataxic effects in wild type mice.

  • Purity

    > 98%
  • General notes

    Protect from air and light.

  • CAS Number

    92545-30-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo 2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

  • Molecular weight

    390.43
  • Molecular formula

    C21H26O7
  • PubChem identifier

    11440685
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC12CCC3C(=O)OC(CC3(C1C(=O)C(CC2C(=O)OC)O)C)C4=COC=C4
  • Source

    Synthetic

References

This product has been referenced in:

  • Vardy E  et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron 86:936-946 (2015). Read more (PubMed: 25937170) »
  • Ansonoff MA  et al. Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. J Pharmacol Exp Ther 318:641-8 (2006). Read more (PubMed: 16672569) »
  • Béguin C  et al. Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorg Med Chem Lett 16:4679-85 (2006). Read more (PubMed: 16777411) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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