Sanguinarine chloride, PP2C inhibitor (ab141022)

Overview

  • Product name

    Sanguinarine chloride, PP2C inhibitor
  • Description

    Selective PP2C inhibitor
  • Biological description

    Selective PP2C inhibitor. Inhibits MKP-1 (IC50 = 10 μM). Induces cell cycle arrest in the G1 phase. Induces ROS-mediated oxidative stress in growing cells. Shows antiproliferative and cytotoxic effects (IC50 = 7.6 μM for S-G gingival epithelial cells). Shows antitumor effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    5578-73-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
  • Molecular weight

    367.79
  • Molecular formula

    C20H14ClNO4
  • PubChem identifier

    68635
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6.[Cl-]
  • Source

    Synthetic

References

This product has been referenced in:

  • Kalogris C  et al. Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition. Biochem Pharmacol 90:226-34 (2014). Read more (PubMed: 24875448) »
  • Shao J  et al. Inhibitory effects of sanguinarine against the cyanobacterium Microcystis aeruginosa NIES-843 and possible mechanisms of action. Aquat Toxicol 142-143:257-63 (2013). Read more (PubMed: 24060579) »
  • Babich H  et al. Cytotoxicity of sanguinarine chloride to cultured human cells from oral tissue. Pharmacol Toxicol 78:397-403 (1996). Read more (PubMed: 8829200) »

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