Product nameSANT-1, Smoothened and hedgehog signaling antagonist
DescriptionPotent smoothened and hedgehog signaling antagonist
Biological descriptionPotent smoothened and Hh signaling antagonist (KD = 1.2 nM). Attenuates SAG stimulation of Shh-LIGHT2 cells (IC50 = 20 nM). Cell-permeable. SANT-2 also available (ab141481)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Hedgehog signaling
This product has been referenced in:
- Stanton BZ & Peng LF Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst 6:44-54 (2010). Read more (PubMed: 20024066) »
- Rominger CM et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther 329:995-1005 (2009). Read more (PubMed: 19304771) »
- Wilson CW et al. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One 4:e5182 (2009). Read more (PubMed: 19365551) »