Key features and details
- Potent smoothened and hedgehog signaling antagonist
- CAS Number: 304909-07-7
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameSANT-1, Smoothened and hedgehog signaling antagonist
DescriptionPotent smoothened and hedgehog signaling antagonist
Biological descriptionPotent smoothened and Hh signaling antagonist (KD = 1.2 nM). Attenuates SAG stimulation of Shh-LIGHT2 cells (IC50 = 20 nM). Cell-permeable. SANT-2 also available (ab141481)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Hedgehog signaling
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141483 has not yet been referenced specifically in any publications.