Overview

  • Product name

    SANT-1, Smoothened and hedgehog signaling antagonist
  • Description

    Potent smoothened and hedgehog signaling antagonist
  • Biological description

    Potent smoothened and Hh signaling antagonist (KD = 1.2 nM). Attenuates SAG stimulation of Shh-LIGHT2 cells (IC50 = 20 nM). Cell-permeable. SANT-2 also available (ab141481)
  • Purity

    > 98%
  • CAS Number

    304909-07-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Stanton BZ & Peng LF Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst 6:44-54 (2010). Read more (PubMed: 20024066) »
  • Rominger CM  et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther 329:995-1005 (2009). Read more (PubMed: 19304771) »
  • Wilson CW  et al. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One 4:e5182 (2009). Read more (PubMed: 19365551) »

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