Product nameSANT-2, Smoothened receptor antagonist
DescriptionPotent smoothened receptor antagonist
Biological descriptionPotent smoothened receptor antagonist. Allosteric modulation similar to SANT-1 (ab141483). Able to displace smo- [3H]SAG-1.3 and [3H]Cyclopamine binding (Ki values are 7.8 and 8.4 nM respectively).
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Hedgehog signaling
This product has been referenced in:
- Rominger CM et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther 329:995-1005 (2009). Read more (PubMed: 19304771) »
- Büttner A et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem 17:4943-54 (2009). Read more (PubMed: 19541490) »
- Chen JK et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A 99:14071-6 (2002). Read more (PubMed: 12391318) »