Overview

  • Product name

    SANT-2, Smoothened receptor antagonist
  • Description

    Potent smoothened receptor antagonist
  • Biological description

    Potent smoothened receptor antagonist. Allosteric modulation similar to SANT-1 (ab141483). Able to displace smo- [3H]SAG-1.3 and [3H]Cyclopamine binding (Ki values are 7.8 and 8.4 nM respectively).
  • Purity

    > 95%
  • CAS Number

    329196-48-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Rominger CM  et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther 329:995-1005 (2009). Read more (PubMed: 19304771) »
  • Büttner A  et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem 17:4943-54 (2009). Read more (PubMed: 19541490) »
  • Chen JK  et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A 99:14071-6 (2002). Read more (PubMed: 12391318) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141481.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up