Overview

  • Product name

  • Description

    Rabbit polyclonal to SAP102
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 525-803 of Human SAP102.

  • Positive control

    • 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, Mouse brain cell lysates; A431 cells; A549 xenograft.

Properties

Applications

Our Abpromise guarantee covers the use of ab152132 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 90 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
  • Involvement in disease

    Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300189]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
  • Sequence similarities

    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 3 PDZ (DHR) domains.
    Contains 1 SH3 domain.
  • Information by UniProt
  • Database links

  • Alternative names

    • bA291O7.3 antibody
    • bA291O7.3 discs large Drosophila homolog 3 neuroendocrine dlg antibody
    • Discs large Drosophila homolog 3 antibody
    • Discs large homolog 3 neuroendocrine dlg Drosophila antibody
    • Discs large homolog 3 antibody
    • Discs large homolog 3 Drosophila antibody
    • Discs, large homolog 3 (Drosophila) antibody
    • Disks large homolog 3 antibody
    • DLG 3 antibody
    • Dlg3 antibody
    • DLG3_HUMAN antibody
    • KIAA1232 antibody
    • mKIAA1232 antibody
    • MRX 90 antibody
    • MRX antibody
    • MRX90 antibody
    • NE Dlg antibody
    • NEDLG antibody
    • Neuroendocrine dlg antibody
    • Neuroendocrine-DLG antibody
    • OTTHUMP00000023475 antibody
    • OTTHUMP00000023476 antibody
    • OTTHUMP00000023477 antibody
    • SAP 102 antibody
    • SAP-102 antibody
    • SAP102 antibody
    • Synapse associated protein 102 antibody
    • Synapse-associated protein 102 antibody
    • XLMR antibody
    see all

Images

  • Anti-SAP102 antibody (ab152132) at 1/1000 dilution + Molt-4 whole cell lysate at 30 µg

    Predicted band size: 90 kDa



    7.5% SDS PAGE
  • Anti-SAP102 antibody (ab152132) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 90 kDa



    7.5% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded A549 xenograft labeling SAP102 with ab152132 at 1/100 dilution.
  • Immunofluorescent analysis of methanol-fixed A431 cells labeling SAP102 with ab152132 at 1/200 dilution. Lower panel co-stained with Hoechst 33342.

References

ab152132 has not yet been referenced specifically in any publications.

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