Overview

  • Product name
    Anti-SARM antibody
    See all SARM primary antibodies
  • Description
    Rabbit polyclonal to SARM
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to amino acids near the C terminus of Human SARM.

  • Positive control
    • Human Tonsil tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab115561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 79 kDa.
IHC-P Use a concentration of 2 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
  • Tissue specificity
    Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
  • Sequence similarities
    Contains 2 SAM (sterile alpha motif) domains.
    Contains 1 TIR domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
    • Alternative names
      • FLJ36296 antibody
      • KIAA0524 antibody
      • MyD88-5 antibody
      • SAM and ARM-containing protein antibody
      • SAM domain-containing protein 2 antibody
      • SAMD2 antibody
      • SARM 1 antibody
      • SARM1 antibody
      • SARM1_HUMAN antibody
      • Sterile alpha and Armadillo repeat protein antibody
      • sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila antibody
      • sterile alpha and HEAT/Armadillo motifs-containing protein antibody
      • sterile alpha and TIR motif containing 1 antibody
      • Sterile alpha and TIR motif-containing protein 1 antibody
      • Sterile alpha and TIR motifs-containing protein 1 antibody
      • Sterile alpha motif domain-containing protein 2 antibody
      • Tir-1 homolog antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARM antibody (ab115561)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARM antibody (ab115561)
      ab115561, at 2µg/ml, staining SARM in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

    References

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