Anti-SARM antibody (ab115561)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARM antibody (ab115561)

    Key features and details

    • Rabbit polyclonal to SARM
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-SARM antibody
      See all SARM primary antibodies

    • Description

      Rabbit polyclonal to SARM

    • Host species

      Rabbit

    • Tested applications

      Suitable for: IHC-Pmore details

    • Species reactivity

      Reacts with: Human

    • Immunogen

      Synthetic peptide conjugated to KLH, corresponding to amino acids near the C terminus of Human SARM.

    • Positive control

      • Human Tonsil tissue.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab115561 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P Use a concentration of 2 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.

    • Tissue specificity

      Predominantly expressed in kidney and liver. Expressed at lower level in placenta.

    • Sequence similarities

      Contains 2 SAM (sterile alpha motif) domains.
      Contains 1 TIR domain.

    • Cellular localization

      Cytoplasm.
    • Information by UniProt

    • Database links

      • Alternative names

        • FLJ36296 antibody
        • KIAA0524 antibody
        • MyD88-5 antibody
        • SAM and ARM-containing protein antibody
        • SAM domain-containing protein 2 antibody
        • SAMD2 antibody
        • SARM 1 antibody
        • SARM1 antibody
        • SARM1_HUMAN antibody
        • Sterile alpha and Armadillo repeat protein antibody
        • sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila antibody
        • sterile alpha and HEAT/Armadillo motifs-containing protein antibody
        • sterile alpha and TIR motif containing 1 antibody
        • Sterile alpha and TIR motif-containing protein 1 antibody
        • Sterile alpha and TIR motifs-containing protein 1 antibody
        • Sterile alpha motif domain-containing protein 2 antibody
        • Tir-1 homolog antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARM antibody (ab115561)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARM antibody (ab115561)
        ab115561, at 2µg/ml, staining SARM in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

      References (1)

      Publishing research using ab115561? Please let us know so that we can cite the reference in this datasheet.

      ab115561 has been referenced in 1 publication.

      • Morale MG  et al. HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis. Sci Rep 8:3476 (2018). WB . PubMed: 29472602

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