Anti-SARM antibody (ab115561)
- Datasheet
- References (1)
- Protocols
Overview
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Product name
Anti-SARM antibody
See all SARM primary antibodies -
Description
Rabbit polyclonal to SARM -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide conjugated to KLH, corresponding to amino acids near the C terminus of Human SARM.
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Positive control
- Human Tonsil tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -80°C. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Ion Exchange Chromatography -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab115561 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 79 kDa. | |
| IHC-P | Use a concentration of 2 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation. -
Tissue specificity
Predominantly expressed in kidney and liver. Expressed at lower level in placenta. -
Sequence similarities
Contains 2 SAM (sterile alpha motif) domains.
Contains 1 TIR domain. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 23098 Human
- Omim: 607732 Human
- SwissProt: Q6SZW1 Human
- Unigene: 446689 Human
- Unigene: 743510 Human
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Alternative names
- FLJ36296 antibody
- KIAA0524 antibody
- MyD88-5 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARM antibody (ab115561)ab115561, at 2µg/ml, staining SARM in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Datasheets and documents
References
This product has been referenced in:
- Morale MG et al. HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis. Sci Rep 8:3476 (2018). WB . Read more (PubMed: 29472602) »
