Key features and details
- Rabbit polyclonal to SARM
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SARM antibody
See all SARM primary antibodies
DescriptionRabbit polyclonal to SARM
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide conjugated to KLH, corresponding to amino acids near the C terminus of Human SARM.
- Human Tonsil tissue.
Storage instructionsShipped at 4°C. Store at -80°C.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityIon Exchange Chromatography
Our Abpromise guarantee covers the use of ab115561 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 2 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionInvolved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Tissue specificityPredominantly expressed in kidney and liver. Expressed at lower level in placenta.
Sequence similaritiesContains 2 SAM (sterile alpha motif) domains.
Contains 1 TIR domain.
- Information by UniProt
- FLJ36296 antibody
- KIAA0524 antibody
- MyD88-5 antibody
ab115561 has been referenced in 1 publication.
- Morale MG et al. HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis. Sci Rep 8:3476 (2018). WB . PubMed: 29472602