Anti-SARM antibody (ab115561)
Key features and details
- Rabbit polyclonal to SARM
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-SARM antibody
See all SARM primary antibodies -
Description
Rabbit polyclonal to SARM -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide conjugated to KLH, corresponding to amino acids near the C terminus of Human SARM.
-
Positive control
- Human Tonsil tissue.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -80°C. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
Purity
Ion Exchange Chromatography -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
Our Abpromise guarantee covers the use of ab115561 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | Use a concentration of 2 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
-
Function
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation. -
Tissue specificity
Predominantly expressed in kidney and liver. Expressed at lower level in placenta. -
Sequence similarities
Contains 2 SAM (sterile alpha motif) domains.
Contains 1 TIR domain. -
Cellular localization
Cytoplasm. - Information by UniProt
-
Database links
- Entrez Gene: 23098 Human
- Omim: 607732 Human
- SwissProt: Q6SZW1 Human
- Unigene: 446689 Human
- Unigene: 743510 Human
-
Alternative names
- FLJ36296 antibody
- KIAA0524 antibody
- MyD88-5 antibody
see all
Images
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARM antibody (ab115561)ab115561, at 2µg/ml, staining SARM in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Datasheets and documents
References (1)
ab115561 has been referenced in 1 publication.
- Morale MG et al. HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis. Sci Rep 8:3476 (2018). WB . PubMed: 29472602