Key features and details
- Rabbit polyclonal to SARM
- Suitable for: WB, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-SARM antibody
See all SARM primary antibodies
DescriptionRabbit polyclonal to SARM
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Mouse, Human
Synthetic peptide (Human) (C terminal).
- Daudi cells
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab17812 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 80 kDa.|
|ICC/IF||Use a concentration of 2 µg/ml.|
FunctionInvolved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Tissue specificityPredominantly expressed in kidney and liver. Expressed at lower level in placenta.
Sequence similaritiesContains 2 SAM (sterile alpha motif) domains.
Contains 1 TIR domain.
- Information by UniProt
- FLJ36296 antibody
- KIAA0524 antibody
- MyD88-5 antibody
Western Blot of Daudi cell lysate labeling SARM with Anti-SARM antibody (ab17812) at (1) 0.5 and (2) 1µg/ml.
Lane 1 : Anti-SARM antibody (ab17812) at 0.5 µg/ml
Lane 2 : Anti-SARM antibody (ab17812) at 1 µg/ml
Lane 3 : Anti-SARM antibody (ab17812) at 2 µg/ml
All lanes : Daudi cell lysate
Predicted band size: 80 kDa
Observed band size: 80 kDa
Western blot analysis of SARM (79 kDa) in Daudi cell lysates with ab17812 at (A) 0.5, (B) 1, and (C) 2
ab17812 at 2µg/ml staining of SARM in Daudi cells by ICC/IF
ab17812 has been referenced in 2 publications.
- Liu M et al. Overexpression of miR-422a inhibits cell proliferation and invasion, and enhances chemosensitivity in osteosarcoma cells. Oncol Rep 36:3371-3378 (2016). PubMed: 27779704
- de Vos AF et al. In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands. J Immunol 183:533-42 (2009). WB ; Human . PubMed: 19542464