Key features and details
- Rabbit polyclonal to SARM
- Suitable for: WB, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-SARM antibody
See all SARM primary antibodies
DescriptionRabbit polyclonal to SARM
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Mouse, Human
Synthetic peptide (Human) (C terminal).
- Daudi cells
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab17812 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 80 kDa.|
|ICC/IF||Use a concentration of 2 µg/ml.|
FunctionInvolved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Tissue specificityPredominantly expressed in kidney and liver. Expressed at lower level in placenta.
Sequence similaritiesContains 2 SAM (sterile alpha motif) domains.
Contains 1 TIR domain.
- Information by UniProt
- FLJ36296 antibody
- KIAA0524 antibody
- MyD88-5 antibody
Western Blot of Daudi cell lysate labeling SARM with Anti-SARM antibody (ab17812) at (1) 0.5 and (2) 1µg/ml.
Lane 1 : Anti-SARM antibody (ab17812) at 0.5 µg/ml
Lane 2 : Anti-SARM antibody (ab17812) at 1 µg/ml
Lane 3 : Anti-SARM antibody (ab17812) at 2 µg/ml
All lanes : Daudi cell lysate
Predicted band size: 80 kDa
Observed band size: 80 kDa
Western blot analysis of SARM (79 kDa) in Daudi cell lysates with ab17812 at (A) 0.5, (B) 1, and (C) 2
ab17812 at 2µg/ml staining of SARM in Daudi cells by ICC/IF
ab17812 has been referenced in 2 publications.
- Liu M et al. Overexpression of miR-422a inhibits cell proliferation and invasion, and enhances chemosensitivity in osteosarcoma cells. Oncol Rep 36:3371-3378 (2016). PubMed: 27779704
- de Vos AF et al. In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands. J Immunol 183:533-42 (2009). WB ; Human . PubMed: 19542464