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  1. Link

    sars-spike-glycoprotein-antibody-c-terminal-ab252690.pdf

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Microbiology Organism Virus RNA Virus ssRNA positive strand virus SARS Coronavirus
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Anti-SARS spike glycoprotein antibody - C-terminal (ab252690)

  • Datasheet
Reviews (2) Submit a question References (4)

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Find out more.

Key features and details

  • Rabbit polyclonal to SARS spike glycoprotein - C-terminal
  • Suitable for: ELISA
  • Isotype: IgG

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Overview

  • Product name

    Anti-SARS spike glycoprotein antibody - C-terminal
    See all SARS spike glycoprotein primary antibodies
  • Description

    Rabbit polyclonal to SARS spike glycoprotein - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ELISAmore details
  • Species reactivity

    Reacts with: SARS-CoV
  • Immunogen

    Synthetic peptide corresponding to Human SARS spike glycoprotein (C terminal).
    Database link: P59594

  • General notes

    Applications overview

    Tick: Tested and Guaranteed to work      X: Will not work      —: No data      Reviews: Customers have been successful and shared their AbReview

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • SARS Coronavirus
    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • Other viruses

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab252690 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
Use at an assay dependent concentration.

ab252690 will detect 10 ng of free peptide at 1 µg/mL.

Notes
ELISA
Use at an assay dependent concentration.

ab252690 will detect 10 ng of free peptide at 1 µg/mL.

Target

  • Relevance

    A novel coronavirus has been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive stranded RNA approximately 27 to 31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.
  • Alternative names

    • E2 antibody
    • E2 glycoprotein antibody
    • Human coronavirus spike glycoprotein antibody
    • S antibody
    • S glycoprotein antibody
    • Spike glycoprotein antibody
    see all

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (4)

Publishing research using ab252690? Please let us know so that we can cite the reference in this datasheet.

ab252690 has been referenced in 4 publications.

  • Wettstein L  et al. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. Nat Commun 12:1726 (2021). PubMed: 33741941
  • Rauch S  et al. mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents. NPJ Vaccines 6:57 (2021). PubMed: 33863911
  • Ke Z  et al. Structures and distributions of SARS-CoV-2 spike proteins on intact virions. Nature 588:498-502 (2020). PubMed: 32805734
  • Pellegrini L  et al. SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids. Cell Stem Cell 27:951-961.e5 (2020). PubMed: 33113348

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

1-2 of 2 Abreviews or Q&A

Western blot abreview for Anti-SARS spike glycoprotein antibody - C-terminal

Average
Abreviews
Abreviews
abreview image
Application
Western blot
Sample
Human Cell lysate - whole cell (HEK293T)
Gel Running Conditions
Non-reduced Denaturing (4-20)
Loading amount
30 µg
Treatment
expressing spike SARS CoV-2
Specification
HEK293T
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 21°C
Read More
The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

Mr. Lawrence Welch

Verified customer

Submitted May 21 2020

Immunocytochemistry/ Immunofluorescence abreview for Anti-SARS spike glycoprotein antibody - C-terminal

Good
Abreviews
Abreviews
abreview image
Application
Immunocytochemistry/ Immunofluorescence
Sample
Human Cell (HeLa expressing Spike-HA from SARS-Cov2)
Permeabilization
Yes - Triton x 100
Specification
HeLa expressing Spike-HA from SARS-Cov2
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
Fixative
Paraformaldehyde
Read More
The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

Abcam user community

Verified customer

Submitted May 19 2020

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