Anti-SART3 antibody (ab84671)
Key features and details
- Rabbit polyclonal to SART3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-SART3 antibody
See all SART3 primary antibodies -
Description
Rabbit polyclonal to SART3 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Chimpanzee, Orangutan -
Immunogen
Synthetic peptide corresponding to a region between residue 600 and 650 of Human SART3 (NP_055521.1)
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Positive control
- IHC: Human pancreatic islet tumour tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab84671 was affinity purified using an epitope specific to SART3 immobilized on solid support -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab84671 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. -
Tissue specificity
Ubiquitously expressed. -
Involvement in disease
Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin. -
Sequence similarities
Contains 8 HAT repeats.
Contains 2 RRM (RNA recognition motif) domains. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Cytoplasm. Nucleus speckle. Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver. - Information by UniProt
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Database links
- Entrez Gene: 467123 Chimpanzee
- Entrez Gene: 9733 Human
- Omim: 611684 Human
- SwissProt: Q15020 Human
- SwissProt: Q5REG1 Orangutan
- Unigene: 584842 Human
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Alternative names
- DSAP1 antibody
- hSART 3 antibody
- hSART-3 antibody
see all
Images
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ab84671 at 1/100 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunofluorescence. Detection: Redfluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody at a dilution of 1/100.
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ab84671 at 1/100 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunohistochemistry. Detection: DAB staining
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ab84671 at 1/250 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunohistochemistry. Detection: DAB staining
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab84671 has not yet been referenced specifically in any publications.