Key features and details
- Rabbit polyclonal to SART3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SART3 antibody
See all SART3 primary antibodies
DescriptionRabbit polyclonal to SART3
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Chimpanzee, Orangutan
Synthetic peptide corresponding to a region between residue 600 and 650 of Human SART3 (NP_055521.1)
- Human Controls: Breast Carcinoma, Colon Carcinoma, Linitis Plastica Stomach Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma, Skin Basal Cell Carcinoma, Stomach Adenocarcinoma, Testicular Seminoma
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab84671 was affinity purified using an epitope specific to SART3 immobilized on solid support
Our Abpromise guarantee covers the use of ab84671 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Epitope exposure with citrate buffer will enhance staining and is recommended.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionRegulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.
Tissue specificityUbiquitously expressed.
Involvement in diseaseDefects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.
Sequence similaritiesContains 8 HAT repeats.
Contains 2 RRM (RNA recognition motif) domains.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationCytoplasm. Nucleus speckle. Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.
- Information by UniProt
- DSAP1 antibody
- hSART 3 antibody
- hSART-3 antibody
ab84671 at 1/100 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunofluorescence. Detection: Redfluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody at a dilution of 1/100.
ab84671 at 1/100 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunohistochemistry. Detection: DAB staining
ab84671 at 1/250 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunohistochemistry. Detection: DAB staining
ab84671 has not yet been referenced specifically in any publications.