Product nameAnti-SAX antibody
DescriptionRabbit polyclonal to SAX
Tested applicationsSuitable for: IHC-FoFr, WB, IP, ICCmore details
Species reactivityReacts with: Drosophila melanogaster
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
Antibody stabilization buffer, with preservatives, consisting of Hepes, NaCl, KCl, glycerol, BSA and chaotropic agents. Preservative: 0.01% Thimerosal (merthiolate)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab42105 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-FoFr: Use at an assay dependent dilution (PMID 19619497).
WB: 1/500. Detects a band of approximately 61-65 kDa (predicted molecular weight: 64 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceSAX (saxophone) protein is a receptor for dpp. In Drosophila, the saxophone gene encodes a type I receptor that mediates signaling by decapentaplegic (dpp), a member of the bone morphogenetic protein (BMP) subgroup of TGF beta-type factors. Over expression or mutation in dpp suppress germline stem cell differentiation. The Saxophone gene is expressed ubiquitously. The Saxophone gene gives two products Brk43E and Berk25 and both gene products interact with TGF super family peptide ligands Dpp. Mutations that completely abolish Saxophone activity cause phenotypes that are similar to partial or complete loss of activity of the dpp ligand. The saxophone products have serine threonine kinase activity responsible for phosphorylation and activation of ligands including pMAD, Screw (Scw), and short gastrulation protein (Sog).
Cellular localizationMembrane; single-pass type I membrane protein
- CG1891 antibody
- receptor protein serine/threonine kinase antibody
- saxophone antibody
- X linked surface antigen antibody
This product has been referenced in:
- Tracy Cai X et al. AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis. Nat Commun 10:2988 (2019). Read more (PubMed: 31278345) »
- Iovino N et al. miR-184 has multiple roles in Drosophila female germline development. Dev Cell 17:123-33 (2009). IHC-FoFr ; Drosophila melanogaster . Read more (PubMed: 19619497) »