Key features and details
- p38 MAPK inhibitor
- CAS Number: 152121-47-6
- Purity: > 98%
- Supplied in DMSO (10 mM)
- Form / State: Solid
- Source: Synthetic
Product nameSB 203580 (DMSO solution), p38 MAPK inhibitor
Descriptionp38 MAPK inhibitor
Cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1, RIP2, c-Raf and GSK3.
Also available as a solid (ab120162).
Storage instructionsStore at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewSupplied in DMSO (10 mM)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146589 has been referenced in 2 publications.
- Iriondo O et al. TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. Nat Commun 9:1994 (2018). PubMed: 29777109
- Wei S et al. Novel Zinc Finger Transcription Factor ZFP580 Facilitates All-Trans Retinoic Acid -Induced Vascular Smooth Muscle Cells Differentiation by Rara-Mediated PI3K/Akt and ERK Signaling. Cell Physiol Biochem 50:2390-2405 (2018). PubMed: 30423583