Overview

  • Product name

    SB 216763, GSK3 inhibitor
  • Description

    Potent selective GSK3 inhibitor
  • Biological description

    Potent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
  • Purity

    > 98%
  • CAS Number

    280744-09-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • Molecular weight

    371.22
  • Molecular formula

    C19H12Cl2N2O2
  • PubChem identifier

    176158
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Clc1ccc(c(Cl)c1)C=4C(=O)NC(=O)C=4c3cn(C)c2ccccc23
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gross ER  et al. Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion. Am J Physiol Heart Circ Physiol 294:H1497-500 (2008). Read more (PubMed: 18223186) »
  • Zhu LQ  et al. Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J Neurosci 27:12211-20 (2007). Read more (PubMed: 17989287) »
  • Coghlan MP  et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803 (2000). Read more (PubMed: 11033082) »
See all 3 Publications for this product

Customer reviews and Q&As

Question
Answer

Thank you for contacting us.

Our biochemical compounds are not made in a sterile environment, and as such we would recommend that sterilisation measures are taken prior to use, if a sterile solution is needed.


I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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