SB 243213 dihydrochloride, 5HT2C receptor antagonist (ab141291)

Overview

  • Product name

    SB 243213 dihydrochloride, 5HT2C receptor antagonist
  • Description

    Potent, selective 5HT2C receptor antagonist
  • Biological description

    Potent, selective 5-HT2C receptor antagonist (Ki = 1 nM). Neurological agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    200940-23-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-indole-1-carboxamide dihydrochloride
  • Molecular weight

    501.33
  • Molecular formula

    C22H19F3N4O2.2HCl
  • PubChem identifier

    15981450
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cl.Cc4ncccc4Oc1ccc(cn1)NC(=O)N3CCc2cc(C)c(cc23)C(F)(F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Goodacre CJ  et al. A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists. Bioorg Med Chem Lett 15:4989-93 (2005). Read more (PubMed: 16168649) »
  • Smith MI  et al. Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine. Pharmacol Biochem Behav 71:599-605 (2002). Read more (PubMed: 11888551) »
  • Wood MD  et al. SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology 41:186-99 (2001). Read more (PubMed: 11489455) »

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