Overview

  • Product name

    SB 271046 hydrochloride, 5-HT6 antagonist
  • Description

    Potent, selective 5-HT6 antagonist
  • Biological description

    Potent and selective 5-HT6 receptor antagonist (Ki = 1-2 nM). Displays >200-fold selectivity for 5-HT6 receptors (vs. other receptor binding sites and ion channels). Poor penetration of the blood-brain barrier. Nootropic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    209481-24-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Da Silva Costa-Aze V  et al. Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice. Behav Brain Res 222:134-40 (2011). Read more (PubMed: 21443908) »
  • Routledge C  et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol 130:1606-12 (2000). Read more (PubMed: 10928964) »
  • Bromidge SM  et al. 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J Med Chem 42:202-5 (1999). Read more (PubMed: 9925723) »

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