Overview

  • Product name

    SB 408124, non-peptide OX1 antagonist
  • Description

    Selective, non-peptide OX1 antagonist
  • Biological description

    Selective, non-peptide orexin receptor 1 (OX1) antagonist (Ki = 26.9 nM). Displays 50-fold selectivity over OX2 (Kb values are 21.7 and 1405 nM for OX1 and OX2, respectively).
  • Purity

    > 98%
  • CAS Number

    288150-92-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kis GK  et al. The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. Pflugers Arch 463:531-6 (2012). Read more (PubMed: 22350729) »
  • Dugovic C  et al. Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J Pharmacol Exp Ther 330:142-51 (2009). Read more (PubMed: 19363060) »
  • Langmead CJ  et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol 141:340-6 (2004). Read more (PubMed: 14691055) »

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