- References (1)
Product nameSB 415286, GSK3 inhibitor
DescriptionPotent, selective GSK3 inhibitor
Biological descriptionPotent, selective GSK3 inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Neuroprotective and antioxidant properties. Also able to stimulate glycogen synthesis and gene transcription. Cell-permeable.
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- PI3K/Akt signaling
- Glycogen synthase kinase
This product has been referenced in:
- Mirlashari MR et al. Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway. Leuk Res 36:499-508 (2012). Read more (PubMed: 22177455) »
- Forde JE & Dale TC Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 64:1930-44 (2007). Read more (PubMed: 17530463) »
- Cross DA et al. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J Neurochem 77:94-102 (2001). Read more (PubMed: 11279265) »
- Coghlan MP et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803 (2000). Read more (PubMed: 11033082) »