Overview

  • Product name

    SB 415286, GSK3 inhibitor
  • Description

    Potent, selective GSK3 inhibitor
  • Biological description

    Potent, selective GSK3 inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Neuroprotective and antioxidant properties. Also able to stimulate glycogen synthesis and gene transcription. Cell-permeable.
  • Purity

    > 99%
  • CAS Number

    264218-23-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mirlashari MR  et al. Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway. Leuk Res 36:499-508 (2012). Read more (PubMed: 22177455) »
  • Forde JE & Dale TC Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 64:1930-44 (2007). Read more (PubMed: 17530463) »
  • Cross DA  et al. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J Neurochem 77:94-102 (2001). Read more (PubMed: 11279265) »
  • Coghlan MP  et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803 (2000). Read more (PubMed: 11033082) »
See 1 Publication for this product

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