Overview

  • Product name

    SB 505124, ALK5 inhibitor
  • Description

    Potent, reversible, competitive ALK5 inhibitor
  • Biological description

    Potent, reversible, competitive ALK5 inhibitor (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Inhibits ALK7 but not ALK1, 2, 3, or 6. Shows antifibrotic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    694433-59-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Uchinaka A  et al. Tissue inhibitor of metalloproteinase-1 and -3 improves cardiac function in an ischemic cardiomyopathy model rat. Tissue Eng Part A 20:3073-84 (2014). Read more (PubMed: 24814095) »
  • Zhang S  et al. TGF-ß signaling pathway as a pharmacological target in liver diseases. Pharmacol Res 85:15-22 (2014). Read more (PubMed: 24844437) »
  • DaCosta Byfield S  et al. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol 65:744-52 (2004). Read more (PubMed: 14978253) »

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