Overview

  • Product name

    SB-525334, TGFBR1 inhibitor.
  • Description

    Cell permeable, potent, selective TGFBR1 inhibitor.
  • Purity

    > 98%
  • CAS Number

    356559-20-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
  • Molecular weight

    343.42
  • Molecular formula

    C21H21N5
  • PubChem identifier

    9967941
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 85 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
  • Source

    Synthetic

References

This product has been referenced in:

  • Kim YJ  et al. Transforming growth factor beta receptor I inhibitor sensitizes drug-resistant pancreatic cancer cells to gemcitabine. Anticancer Res 32:799-806 (2012). Read more (PubMed: 22399597) »
  • Thomas M  et al. Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. Am J Pathol 174:380-9 (2009). Read more (PubMed: 19116361) »
  • Higashiyama H  et al. Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis. Exp Mol Pathol 83:39-46 (2007). Read more (PubMed: 17274978) »
  • Grygielko ET  et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther 313:943-51 (2005). Read more (PubMed: 15769863) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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