Overview

  • Product name

    SB 590885, B-Raf kinase inhibitor
  • Description

    Potent and selective B-Raf kinase inhibitor
  • Biological description

    Potent and selective B-Raf kinase inhibitor (Ki = 0.16 nM). Inhibits anchorage-independent cancer cell growth. Inhibits ERK phosphorylation, Shows antiproliferative effects. Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    405554-55-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Aoki K  et al. Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Mol Cell 52:529-40 (2013). Read more (PubMed: 24140422) »
  • Villanueva J  et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18:683-95 (2010). Read more (PubMed: 21156289) »
  • King AJ  et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res 66:11100-5 (2006). Read more (PubMed: 17145850) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145185.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up