Overview

  • Product name

    SB 743921 hydrochloride, KIF11 inhibitor
  • Description

    Potent kinesin spindle protein KIF11 inhibitor
  • Biological description

    Potent kinesin spindle protein KIF11 inhibitor (Ki = 0.1 nM). Induces mitotic arrest and apoptosis. Suppresses ERK and AKT activity. Shows antiproliferative effects. Shows antitumor effects in vivo.
  • Purity

    > 95%
  • CAS Number

    940929-33-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ma HT  et al. Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance. Mol Oncol 8:1404-18 (2014). Read more (PubMed: 24950801) »
  • Yin Y  et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma :1-8 (2014). Read more (PubMed: 25146433) »
  • Good JA  et al. Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem 56:1878-93 (2013). Read more (PubMed: 23394180) »

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