Key features and details
- ALK inhibitor
- CAS Number: 301836-41-9
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameSB431542, ALK inhibitor
Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7. 3D Growth matrix component; also component of brain and blood vessel organoid differentiation media.
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120163 has been referenced in 24 publications.
- Liberti DC et al. Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury. Cell Rep 35:109092 (2021). PubMed: 33979629
- Keatinge M et al. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genet 17:e1009515 (2021). PubMed: 33914736
- Abarca-Buis R et al. Control of fibrosis by TGFß signalling modulation promotes redifferentiation during limited regeneration of mouse ear. Int J Dev Biol 64:423-432 (2020). PubMed: 33063836
- Xiang Y et al. Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons. Mol Cell 79:84-98.e9 (2020). PubMed: 32526163
- Katsura H et al. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell 27:890-904.e8 (2020). PubMed: 33128895