Key features and details
- ALK inhibitor
- CAS Number: 301836-41-9
- Purity: > 99%
- Supplied in DMSO (10 mM)
- Form / State: Solid
- Source: Synthetic
Product nameSB431542 (DMSO solution), ALK inhibitor
Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.
Also available as a solid (ab120163).
Storage instructionsStore at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewSupplied in DMSO (10 mM)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146590 has been referenced in 2 publications.
- Malaguti M et al. Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation. Dev Cell 50:462-477.e5 (2019). PubMed: 31204172
- Kelly TJ et al. Temporal Control of the TGF-ß Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities. Cell Rep 29:2702-2717.e7 (2019). PubMed: 31775039