Overview

  • Product name

    SC-10, PKC activator
  • Description

    Potent, cell-permeable Ca2+-dependent PKC activator
  • Biological description

    Potent, cell-permeable Ca2+-dependent PKC activator. Restores novobiocin (ab143194) inhibited hTERT-hsp90 interaction in telomerase holoenzyme.
  • CAS Number

    102649-79-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Chloro-N-heptylnaphthalene-1-sulfonamide
  • Molecular weight

    339.88
  • Molecular formula

    C17H22ClNO2S
  • PubChem identifier

    5175
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCNS(=O)(=O)C1=CC=CC2=C1C=CC=C2Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chang JT  et al. hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells. Br J Cancer 94:870-8 (2006). Read more (PubMed: 16508638) »
  • Papp A & Hoyer J PKC-dependent reduction of the acetylcholine-evoked inward Na current in Aplysia D-neurons: effect of injected PKC and PKC activators. Brain Res 708:123-7 (1996). Read more (PubMed: 8720867) »
  • Watson PH  et al. Activation and inhibition of protein kinase C in cultured bovine parathyroid cells: effect on the release of C-terminal fragments of parathyroid hormone. J Bone Miner Res 7:667-74 (1992). Read more (PubMed: 1414485) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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