Overview

  • Product name

    SC-51089, EP1 receptor antagonist
  • Description

    Selective EP1 receptor antagonist
  • Biological description

    Selective EP1 receptor antagonist (Ki values are 1.3 (EP1), 61.1 (EP2), 17.5 (EP3) and >100 μM (EP4). Active in vitro and centrally in vivo. Attenuates neurotoxicity and is an antitumorigenic agent.
  • Purity

    > 98%
  • CAS Number

    146033-02-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Chloro-N'-(3-pyridin-4-ylpropanoyl)-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide hydrochloride
  • Molecular weight

    459.30
  • Molecular formula

    C22H19ClN4O3.HCl
  • PubChem identifier

    132748
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C2=CC=CC=C2OC3=C(N1C(=O)NNC(=O)CCC4=CC=NC=C4)C=C(C=C3)Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li X  et al. Antagonism of Neuronal Prostaglandin E2 Receptor Subtype 1 Mitigates Amyloid ß Neurotoxicity In Vitro. J Neuroimmune Pharmacol 8:87-93 (2013). Read more (PubMed: 22718277) »
  • Matsuo M  et al. Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089. J Neurooncol 66:285-92 (2004). Read more (PubMed: 15015658) »
  • Abramovitz M  et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483:285-93 (2000). Read more (PubMed: 10634944) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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