Overview

  • Product name

    SC-51322, EP1 receptor antagonist
  • Description

    Potent, selective EP1 receptor antagonist
  • Biological description

    Potent, selective EP1 receptor antagonist (Ki values are 13.8 and 698 nM for EP1 and EP3 receptors respectively). One hundred times more potent than SC-51089. Potentiates PGE2 induced vascular relaxation and has analgesic activity. Active in vitro and centrally active in vivo.
  • Purity

    > 98%
  • CAS Number

    146032-79-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Foudi N  et al. Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype. Br J Pharmacol 154:1631-9 (2008). Read more (PubMed: 18516068) »
  • Hefferan MP  et al. Spinal nerve injury activates prostaglandin synthesis in the spinal cord that contributes to early maintenance of tactile allodynia. Pain 101:139-47 (2003). Read more (PubMed: 12507708) »
  • Abramovitz M  et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483:285-93 (2000). Read more (PubMed: 10634944) »

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