Overview

  • Product name

    SC-560, COX-1 inhibitor
  • Description

    Highly selective COX-1 inhibitor
  • Biological description

    Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 9 nM and 6.3 μM for COX-1 and COX-2, respectively). Displays anti-inflammatory, antitumor and antiviral activity. Orally active.
  • Purity

    > 99%
  • CAS Number

    188817-13-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Okamoto M  et al. Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560. Antivir Chem Chemother 20:47-54 (2009). Read more (PubMed: 19794231) »
  • Choi SH  et al. Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J 22:1491-501 (2008). Read more (PubMed: 18162486) »
  • Brenneis C  et al. Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. FASEB J 20:1352-60 (2006). Read more (PubMed: 16816110) »
  • Daikoku T  et al. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res 65:3735-44 (2005). Read more (PubMed: 15867369) »

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