Overview

  • Product name

    SC-9, PKC activator
  • Description

    Selective Ca2+-dependent PKC activator
  • Biological description

    Selective Ca2+-dependent PKC activator (Km = 5.8 μM, myosin light chain substrate). Reduces spermatozoa mobility. Inhibits the acrosome reaction.
  • CAS Number

    102649-78-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Chloro-N-(6-phenylhexyl)naphthalene-1-sulfonamide
  • Molecular weight

    401.95
  • Molecular formula

    C22H24ClNO2S
  • PubChem identifier

    124172
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)CCCCCCNS(=O)(=O)C2=CC=CC3=C2C=CC=C3Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ashizawa K  et al. Regulation of acrosome reaction of fowl spermatozoa: evidence for the involvement of protein kinase C and protein phosphatase-type 1 and/or -type 2A. Reproduction 131:1017-24 (2006). Read more (PubMed: 16735541) »
  • Christopher KJ  et al. Involvement of protein kinase C in 5-HT-stimulated ciliary activity in Helisoma trivolvis embryos. J Physiol 515 ( Pt 2):511-22 (1999). Read more (PubMed: 10050017) »
  • Yonemaru M  et al. Protein kinase inhibitor attenuates an increase in endothelial monolayer permeability induced by tumour necrosis factor-alpha. Respirology 2:63-9 (1997). Read more (PubMed: 9424406) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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