SC79, Akt activator (ab146428)
Key features and details
- Akt activator
- CAS Number: 305834-79-1
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SC79, Akt activator -
Description
Akt activator -
Biological description
Akt activator. Binds to the pleckstrin homology domain. Suppress excitotoxicity-induced neuronal death. Shows neuroprotective effects in vivo. Blood-brain barrier permeable. -
CAS Number
305834-79-1 -
Chemical structure
Properties
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Chemical name
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester -
Molecular weight
364.80 -
Molecular formula
C17H17ClN2O5 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Images
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Chemical Structure - SC79, Akt activator (ab146428)2D chemical structure image of ab146428, SC79, Akt activator
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab146428 has been referenced in 6 publications.
- Zhao Y et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Mol Med Rep 23:N/A (2021). PubMed: 33880579
- Wang F et al. lncRNA CADM1-AS1 inhibits cell-cycle progression and invasion via PTEN/AKT/GSK-3ß axis in hepatocellular carcinoma. Cancer Manag Res 11:3813-3828 (2019). PubMed: 31118799
- Sun Z et al. Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. Clin Sci (Lond) 133:1167-1184 (2019). PubMed: 31076460
- Gamero-Estevez E et al. Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31581662
- Niu S et al. Beta-Arrestin 1 Mediates Liver Thyrotropin Regulation of Cholesterol Conversion Metabolism via the Akt-Dependent Pathway. Int J Endocrinol 2018:4371396 (2018). PubMed: 29853881
- Xu F et al. Pectolinarigenin inhibits non-small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncol Rep 40:3458-3468 (2018). PubMed: 30542737