Key features and details
- Akt activator
- CAS Number: 305834-79-1
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameSC79, Akt activator
Biological descriptionAkt activator. Binds to the pleckstrin homology domain. Suppress excitotoxicity-induced neuronal death. Shows neuroprotective effects in vivo. Blood-brain barrier permeable.
Chemical name2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146428 has been referenced in 4 publications.
- Wang F et al. lncRNA CADM1-AS1 inhibits cell-cycle progression and invasion via PTEN/AKT/GSK-3ß axis in hepatocellular carcinoma. Cancer Manag Res 11:3813-3828 (2019). PubMed: 31118799
- Sun Z et al. Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. Clin Sci (Lond) 133:1167-1184 (2019). PubMed: 31076460
- Niu S et al. Beta-Arrestin 1 Mediates Liver Thyrotropin Regulation of Cholesterol Conversion Metabolism via the Akt-Dependent Pathway. Int J Endocrinol 2018:4371396 (2018). PubMed: 29853881
- Xu F et al. Pectolinarigenin inhibits non-small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncol Rep 40:3458-3468 (2018). PubMed: 30542737