Overview

  • Product name

  • Description

    Rabbit polyclonal to SCA10
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant fragment corresponding to Human SCA10 aa 1-393.
    Database link: Q9UBB4

  • Positive control

    • 293T whole cell lysate, A431 whole cell lysate, HeLa whole cell lysate, HepG2 whole cell lysate, paraffin-embedded Human colon carcinoma tissue.
  • General notes

     This product was previously labelled as ATXN10

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 79% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab153875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 53 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
  • Tissue specificity

    Expressed in the central nervous system.
  • Involvement in disease

    Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10) [MIM:603516]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).
  • Sequence similarities

    Belongs to the ataxin-10 family.
  • Cellular localization

    Cytoplasm > perinuclear region.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ataxin 10 antibody
    • Ataxin-10 antibody
    • ATX10_HUMAN antibody
    • Atxn10 antibody
    • Brain protein E46 homolog antibody
    • E46L antibody
    • FLJ37990 antibody
    • HUMEEP antibody
    • Like mouse brain protein E46 antibody
    • OTTHUMP00000197383 antibody
    • SCA10 antibody
    • Spinocerebellar ataxia 10 antibody
    • Spinocerebellar ataxia type 10 protein antibody
    see all

Images

  • All lanes : Anti-SCA10 antibody (ab153875) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : HeLa whole cell lysate
    Lane 4 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 53 kDa



    10% SDS PAGE
  • Immunohistochemical analysis of paraffin embedded Human colon cancer tissue labeling SCA10 with ab153875 1/500 dilution

References

ab153875 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab153875.
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