Overview

  • Product name

  • Description

    Rabbit polyclonal to SCA2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment within Human SCA2 (internal sequence). The exact sequence is proprietary.
    Database link: Q99700

  • Positive control

    • WB: A431 whole cell extract. ICC/IF: HCT 116 cells.
  • General notes

     This product was previously labelled as ATX2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab227915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 140 kDa.

Target

  • Function

    Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
  • Tissue specificity

    Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
  • Involvement in disease

    Spinocerebellar ataxia 2
    Amyotrophic lateral sclerosis 13
  • Sequence similarities

    Belongs to the ataxin-2 family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • ASL13 antibody
    • Ataxin 2 antibody
    • Ataxin-2 antibody
    • ATX2_HUMAN antibody
    • Atxn2 antibody
    • Olivopontocerebellar ataxia 2, autosomal dominant antibody
    • SCA2 antibody
    • Spinocerebellar ataxia type 2 protein antibody
    • TNRC13 antibody
    • Trinucleotide repeat containing 13 antibody
    • Trinucleotide repeat containing gene 13 protein antibody
    • Trinucleotide repeat-containing gene 13 protein antibody
    see all

Images

  • Anti-SCA2 antibody (ab227915) at 1/500 dilution + A431 (human epidermoid carcinoma cell line) whole cell extract at 30 µg

    Predicted band size: 140 kDa



    5% SDS-PAGE gel.

  • HCT 116 (human colorectal carcinoma cell line) cells stained for SCA2 (green) using ab227915 at 1/1000 dilution in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

    Nuclear counterstain: Hoechst 33342 (blue).

References

ab227915 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab227915.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up